The inhibitory receptor CD200R educates ILC1s for optimal cytotoxicity

解码CD4+T细胞分化的调控机制

表观修饰酶Setd2靶向磷脂代谢调控T细胞分化平衡

类风湿关节炎中人类 CD4⁺CD25⁺CD161⁺T 细胞的跨组织分布及功能异质性

Innate lymphoid cells originate from fetal liver–derived tissue-resident progenitors

内耳一种极易被误认为黑色素细胞的巨噬细胞

HS1BP3通过下调SIRT1-FOXO3通路激活从而增强记忆T细胞的形成和抗肿瘤功能

树突状细胞在基质微环境下的分化转归

Inhibition of LARP4-mediated quiescence exit of naïve CD4+ T cells ameliorates autoimmune and allergic diseases

GSDME缺失调节B细胞的BCR信号转导和抗病毒反应

巨噬细胞CCRL2通过促进NLRP3炎症小体活化加重动脉粥样硬化

Neonate-like B cells reverse aging-associated decline of heart regeneration via S100A4-mediated cardiomyocyte metabolic rewiring

Brain-cervical lymph node crosstalk contributes to brain injury-induced by subarachnoid hemorrhage

Cardiac Resident Macrophages Produce Collagen I And Contribute To Vascular Maturation Following Myocardial Infarction

Macrophage ferroptosis potentiates GCN2 deficiency induced pulmonary venous arterialization

主动脉夹层合并动脉粥样硬化的细胞分子靶点研究

Biphasic Association of LDL/oxLDL-Linked Endothelial Injury and γδ T Immune Programs with Myocardial Infarction Outcomes

E3 Ligase Rbx1 Orchestrates Thymus Development and Fate Determination of αβ-γδ T Cells

RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ

ATF3 Restrains ILC1 Potency in Ameliorating CD8+T Cell-Mediated Viral Hepatitis

Dietary fiber targeting microbiota metabolism shapes STING-dependent innate immune responses

Maternal macrophages drive intrauterine fetal quality selection

RNF123介导的NEK7非锚定K63多聚泛素化修饰抑制炎症小体激活

CPT1A-Mediated Fatty Acid Oxidation in cDC1 Confers Protection Against Dextran Sulfate Sodium-induced Ulcerative Colitis

受体人源化小鼠模型中人I型干扰素不同亚型的体内作用差异图谱解析

IPO4通过调控脂肪酸代谢响应呼吸道RNA病毒天然免疫应答

Novel GSDMD inhibitors target oligomerization interface I to block pyroptosis

Isocyanic acid-mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation

DENDRITIC CELL NK LECTIN GROUP RECEPTOR-1 (DNGR-1) DELETION LIMITS PANCREATIC TISSUE DAMAGE IN CHRONIC PANCREATITIS VIA ABERRANT B CELL ACCUMULATION AND ALTERED TH17 DIFFERENTIATION

Lithium carbonate induces myofibroblast necroptosis to reverse pulmonary fibrosis

Listerin通过促进TLR4 mRNA降解缓解阿尔茨海默病相关神经炎症

SLC44A2 orchestrates pDC migration and type I interferon signaling during homeostasis and viral infection

亚油酸靶向核内DNA识别受体hnRNPA2B1抑制天然免疫应答与自身免疫炎症

Inhibition of P2RX7 Suppresses the Activation of cGAS-STING in Retinal Microglia in Response to Light Damage

E3-RBP泛素化修饰调控天然免疫与炎症的新功能新机制

SARS-CoV-2 rORF3, a novel microprotein, hijacks RanBP2 to block p65 nuclear import and attenuate interferon-β production

Subcellular Distribution of Mitochondrial DNA Determines cGAS-STING Activation Patterns in Microglia and Their Pathological Roles in Alzheimer's Disease

Extracellular GSDMD-NT induces tumor cell pyroptosis via JAK1-STAT1/3-activated TMEM16F-dependent membrane lipid scrambling

Optimization of the humanized mouse model with functional human maternal–fetal interface immunity

肝脏特异性PON1通过代谢重编程解除Treg驱动的肝癌免疫抑制的作用与机制

Senescent NK Cell promotes Tumor Progression and ICB Resistance through Sirt6/Stat3 axis

Promoting Neutrophil Maturation Attenuates Neuroinflammation in an Animal Model of Multiple Sclerosis

nTreg失能与iTreg稳定：嘌呤代谢分叉决定Treg命运及RA治疗新靶点

独特顺式调控元件调控RORγt+抗原呈递细胞维持肠道口服耐受

生物钟蛋白REV-ERB通过Bhlhe40-c-Maf轴调控肠道RORgt+ Treg细胞在炎症性肠病中的分化与功能

IFITM1 Exacerbates Monocyte Inflammation and Drug-Induced Liver Injury by Promoting the Nuclear Translocation of NFATc2

脂肪酸结合蛋白4对训练免疫的调控作用与分子机制

NSUN2 protects from URSA by remodeling fetal-maternal immunotolerance through mediating trophoblasts TGFB1 m5C modification

Sustaining BM NK Cell Surveillance: A PBX1-PTN/OGN Autocrine Loop Enables IL-12 Sensitivity

衰老肿瘤细胞来源外泌体PKM2促进CD8+T细胞功能的研究

DRG1通过上调c-Myc磷酸化水平促进肝癌进展的机制研究

PTEN loss in fibroblasts drives systemic immunosenescence

过继Treg细胞疗法通过抑制IL-2-p-STAT5信号通路增加促炎性Th17细胞分化

Nuclear U1 snRNA facilitates the dimerization of hnRNPA2B1 to enhance anti-DNA viral innate immunity

Glehnia littoralis–Derived α-Mangostin Reprograms Macrophage Metabolism via the CCDC22/NF-κB Axis to Strengthen Anti-Esophageal Squamous Cell Carcinoma Immunity

基于肾小管上皮细胞特异性Six1基因敲除小鼠模型探究Six1在IR-AKI肾脏损伤修复中的作用

精准抑制焦亡GSDMD-NT孔道为炎症控制提供新思路

新型免疫抑制剂SD1治疗输血相关急性肺损伤的效果及其机制探索

肿瘤微环境和宏环境对NK 细胞的影响及干预

G1P驱动糖原及G6PD相分离实现记忆CD8+T细胞磷酸戊糖途径区室化

营养代谢驱动的表观遗传编码决定T细胞抗肿瘤命运

TNFR2阻断可通过靶向高糖酵解肿瘤中乳酸驱动的Treg代谢从而增强抗PD-1的疗效

谷氨酸通过调控Acod1/衣康酸线粒体代谢轴调控树突状细胞骨架重塑及迁移

皮肤角质形成细胞原位生成胆汁酸促进感觉神经增长和炎症反应

Adipocyte Orchestrates Obesity-related Chronic Inflammation through β2-microglobulin

Impaired Mitochondrial OXPHOS in Intrahepatic DNTreg Cells Exacerbates MASLD by Disrupting Histone Acetylation and Immunoregulatory Function

DBC1 integrates IL-33 and NAD⁺ signaling to regulate adipose Treg function and metabolic homeostasis in obesity

One-Carbon Metabolism Regulation in Macrophages and Inflammatory-Related Diseases

Succinate-loaded tumor cell-derived microparticles reprogram tumor-associated macrophage metabolism

大黄素通过提高CD8+ T细胞PLPP1表达 增强PD-1单抗治疗效果的研究

不同膳食糖类的摄入和代谢对辅助T细胞免疫应答的影响

CIA2A optimizes the constitution of membrane glycerophospholipids through phospholipid remodeling to modulate the functionality of dendritic cells

嗜碱性粒细胞自噬缺陷通过调节肠道菌群失衡改善狼疮小鼠代谢

Xbp1 links gut milieu and ILC2 functionality via one-carbon metabolism to counteract colitis

琥珀酸通过诱导表观遗传重塑和线粒体代谢适应性增强CD8⁺ T细胞功能及抗肿瘤免疫机制研究

IDO1 regulating ROS rhythm reveals glycogenolysis-PPP axis as a common target for human cancer treatment

Suppression of Dendritic Cell Antigen Presentation via Lactate-Mediated DNMT1 Lactylation and Epigenetic STAT1 Silencing Drives Immune Evasion in Radioresistant Tumor

重大传染病免疫保护因子及治愈新策略

TBK1吞噬体募集通过与SRC形成正反馈环路增强抗真菌免疫

ATG16L1-mediated Autophagy Affects the Anti-HBV Effect of Dendritic Cells

E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription

Viral Dynamics and Exceptional HBsAg Clearance in Immunotolerant Pediatric HBV: Findings from the Prospective Sprout Project

M.tb protein PPE51 hijacks TRAF6 to restrain host immune for intracellular bacteria growth

基于单细胞转录组揭示肺结核组织免疫微环境图谱

TREM2 promotes foam macrophage formation and T cell exhaustion in Mycobacterium tuberculosis infection

Trefoil factor 2 Interacts with A4GNT to Regulate Inflammation to Protect against Pneumonia during Influenza Virus Infection

SARS-CoV-2特异性CD8+T细胞应答中TCR与肽-MHC结合的化学作用力

抗病毒中和抗体研究

PD-1 is required for the early expansion of HBV-specific CD8+ T cells and does not suppress their effector function during the acute phase of HBV infection

STING驱动的脾脏高表达Nrg4巨噬细胞亚群在疟原虫致病中的作用及机制研究

Salmonella hijacks a host glucose transporter for intravacuolar proliferation

PRRSV NSP5 orchestrates dual immune disruption by targeting NLRP3 and STING

ASS1介导的巨噬细胞极化在CVB3病毒性心肌炎中的作用

The tissue-resident memory like CD3+CD19+ TB cells function as a inflammation inducing subset during infection

Comparison Across Species: SARS‐CoV‐2 Infection Leads to More Significant Myopathological Changes in A Rhesus Monkey Model

Siglec-9 acts as an immune checkpoint marker on MDSCs in Brucella Infection

粒细胞对肿瘤相关脾脏髓系造血的正反馈调节

TOLLIP targets GSDME-NT carried endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy

T细胞与癌症免疫治疗的响应与耐药

EccDNA编码转胺酶TGM2促进组蛋白5-羟色胺化修饰抑制CD8+ T细胞活化导致肿瘤免疫治疗抵抗的机制研究

Extrinsic mechanism of oncogenic KLF7 in promoting advanced progression of HNSCC by remodeling cancer immune microenvironment

Enhanced Formation of Tertiary Lymphoid Structures Shapes the Anti-tumor Microenvironment in Hepatocellular Carcinoma after FOLFOX-HAIC Treatment

Targeting Misshapen/NIK-related kinase MINK1 potentiates sustained anti-tumor CD8+ T cell response

靶向Eif4g2选择性破坏肿瘤Treg细胞的翻译模式增强抗肿瘤免疫能力

肿瘤微环境诱导型免疫检查点分子IGSF9促进肿瘤细胞免疫逃逸机制的研究

ICAM1抑制通过调控β-catenin/PD-L1信号通路降低胶质母细胞瘤干性并增强抗肿瘤免疫

Tumor-derived exosomal fatty acids reprogram neutrophils to promote NETs formation and lung cancer progression

ACAT1调控三级淋巴结构影响肺癌免疫治疗敏感性

IDO1-dependent Activation of Kyn-NFATC2-CXCL8 Signaling Increases Neutrophil Recruitment in Esophageal Squamous Cell Cancer.

mGluR4介导的谷氨酸能信号通过调节树突状细胞成熟重塑肿瘤微环境

Lipid Metabolism Reprogramming Orchestrates CD14⁺ Dendritic Cell Function via STING Pathway in Gastric Tumor Microenvironment

IL-6 combined with IL-8 suppress PD-1 expression on CD8+T cells and induce anti-PD-1 immunotherapy resistance through P-SIK1/c-FOS axis in CRC patients

AMER1 expedites anti-tumor immunity of CD8+ T cells by enhancing cancer cell-derived dopamine secretion in colorectal cancer

Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth

ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

hnRNPA2B1 sustains T cell immunity and enhances cancer immunotherapy via phase separation-mediated epigenetic remodeling

FABP5+巨噬细胞介导肿瘤来源不饱和脂肪酸信号对T细胞抗肿瘤免疫的抑制

SCRN1 confers hepatocellular carcinoma resistance to ferroptosis by stabilizing GPX4 via STK38-mediated phosphorylation

A next-generation anti-CTLA-4 probody effectively mitigates toxicity and facilitates the anti-tumor efficacy

Synergistic Innate-Adaptive Immunity by NKG2D-Specific CAR-Macrophages Drives Durable Remission in Hepatocellular Carcinoma

Enhanced Antitumor Efficacy of GM-CSF-Armed Oncolytic Influenza Virus Combined with Gemcitabine and Its Synergistic Potential with PD-1 Blockade in Pancreatic Ductal Adenocarcinoma

rSiglec-10(V set) armed oncolytic adenovirus improves the effects of virotherapy through enhancing oncolysis and antitumor immunity

Development of an Anti-B7-H3/CD3 Bi-Specific Antibody with Anti-Tumor Efficacy through T Cell Activation and Tumor Infiltration

Targeting tumor-specific T cells with LAG3-directed interleukin-2 prevents T cell exhaustion and reinvigorates antitumor immunity

Predominant mutated non-canonical tumor-specific antigens identified by proteogenomic analysis demonstrate immunogenicity and tumor suppression in CRC

Activated B cells modulate the maturation of MDSCs via CD36-dependent MHC-II transfer to orchestrate CD4+ Th1-dominant antitumor immunity after cryo-thermal therapy

基于病理学筛选胰腺癌免疫治疗新靶点的基础与转化研究

The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps: A Potential Therapeutic Target

高分辨非转移性淋巴结分子分型及其演化规律

新型多抗在肿瘤免疫治疗中的作用与机制研究

B7-H4 Blockade Reverses T Cell Exhaustion and Enhances the Efficacy of Vγ9Vδ2 T Cell Adoptive Therapy in Reprogramming the Immune Microenvironment of Ovarian Cancer

CD40L-armed CAR-Macrophages Synergistically Remodel Tumor Microenvironment and Activate Systemic Immunity in Solid Tumors

HTRA1 remodels the tumor immune microenvironment and regulates the progression of colorectal cancer

LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells

IL-12-Non-Secretory Oncolytic Adenovirus Synergizes with NKG2DL-CAR-NK Cells to Potentiate Anti-tumor Efficacy and Remodel the Immune Microenvironment

LPAR6 Maintains Germinal Center Territory and Controls Plasma Cell Fate

Differential roles of synovial peripheral helper T cells in the ectopic response in rheumatoid arthritis

VNN2表达的外周血单核细胞在原发性干燥综合征中的功能特征及临床意义

Basophilic exosomes promote SLE development via exacerbating B cell activation through the lncRNA ENST00000537616/miR-330-5p/KRAS axis

MDA5 regulates BCR signaling and B cell function via DNM1 mediated by NF-κB

枸杞多糖通过肠道菌群介导的Tfh/B细胞轴调节改善类风湿性关节炎

PAD2-catalyzed histone H4 arginine 3 citrullination contributes to the differentiation of monocytic myeloid-derived suppressor cells

Single-cell analysis identifies LY6E⁺ neutrophils as interferon-responsive mediators of methotrexate resistance in rheumatoid arthritis

脱氢紫堇碱选择性抑制mTOR依赖的Th17免疫应答及其在系统性红斑狼疮中的治疗效果

天然饮食配体DIM活化AHR信号对1型糖尿病调节性T细胞的作用研究

角质形成细胞稳态对系统性自身免疫反应的影响及机制

Data-driven subclassification of systemic lupus erythematosus: integrative clustering and multi-omics analysis in a multicenter cohort

TNFSF14-HVEM/LTβR Exacerbates Keratinocyte Abnormalities and IMQ-Induced Psoriatic Skin Inflammation via Activating NF-κB/TWIST1 Signaling Pathway

Alanine-serine-cysteine transporter 2 promotes systemic lupus erythematosus by supporting CD4+ T cell expansion and Tfh cell generation

Signaling Lymphocyte Activation Molecule Family 7 Mediates IFN-γ-Induced Neutrophil Extracellular Traps and Amplifies Inflammation in Still's Disease

LILRA3通过扩增滤泡辅助性T细胞、外周辅助性T细胞及自身反应性B细胞促进系统性红斑狼疮的发生发展

Neutrophil extracellular traps promote autoimmune hepatitis through inhibiting the suicide of CD8+ T cells

MDSC-derived IFN-β promotes T follicular helper cell response via AhR activation and exacerbates lupus development

MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway

新型免疫抑制剂SD1对胰岛移植血源性炎症及急性排斥反应的阻断效应及其机制研究

靶向巨噬细胞DNMT1减轻同种异体移植物纤维化的机制研究

基因修饰猪-猴异种心脏移植模型免疫反应动态特征分析

八基因编辑猪 - 恒河猴异种肾移植后受体的免疫细胞变化及其与移植肾功能的相关性研究

Macrophages Iron Rewiring Unleashes Allograft Rejection-Mimetic Anti-tumor Immunity

单细胞多组学揭示MR1介导的MAIT细胞在维持肝移植排斥中的重要作用

EBV反应性KIR+ CD8+ T细胞诱导儿童肝移植术后免疫耐受的机制研究

ENPP1 Mediates a Novel Mesenchymal-Like Endometrial Regenerative Cells Derived Exosome Induced cGAMP Hydrolysis in Alleviating Cardiac Allograft Rejection

Targeting CCR8 to Modulate CD8⁺ TRM Cell Accumulation and Promote Immune Tolerance in Solid Organ Transplantation

Lactate Attenuates Hepatic Ischemia-Reperfusion Injury by Reducing Intrahepatic Inflammation and Suppressing Hepatocyte-Neutrophil Interaction via the IL-33/ST2 Pathway

Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in mice

TRIM33通过抑制肺泡巨噬细胞过度活化预防过敏性哮喘

IgE and T Cell Epitope Mapping of Fel d 2, an Important Cross-Reactive Animal Allergen

HECT E3 ubiquitin ligase SMURF2 orchestrates FcεRI-dependent mast cell activation and allergic responses

EphA2 mediates airway inflammation in non-Th2 asthma via the IL-6/IL-8-DC-Th1/Th17 axis

IDO-1/KYN/AHR axis regulates mitochondria-dependent keratinocyte apoptosis in severe drug-induced skin reactions

Micro-arrayed PR10 proteins and peptides for Assessment of Specific Natural and Vaccine-induced Antibody Responses

AhR/CYP1A1/ROS轴依赖的NLRP3炎性焦亡：PM2.5诱导变应性鼻炎上皮屏障损伤的新机制

芸香柚皮苷抑制USP15去泛素化NLRP3缓解变应性鼻炎的机制研究

关于《医学免疫学》研究生课程教学理念和思路的思考

免疫耐受的抗原拓展：从耐受自身到耐受食物

AI赋能的研究生课程建设：复旦大学《癌症免疫学原理和进展》的初步实践

系统论导向的医学免疫学本科课程教学的实践

“一拓二引三观四探”全链培养模式在医学免疫学教学中的构建与实践

抗体教学实施过程的优化与实践

固有免疫系统及其应答--教学新模式的探索与实践

以科研能力培养为导向的医学免疫学八年制实验课教学改革探索

AI智能体在免疫学讨论课教学中的运用

过敏性炎症中造血干祖细胞介导的训练免疫驱动疾病进展及过敏共病的机制研究

嗜酸性粒细胞炎性亚群加强甲流感染中CD8T细胞的免疫损伤作用

多物种结构免疫学研究：从重要模式动物到人类呼吸道病毒的通用疫苗研发

慢性阻塞性肺疾病的早期潜在预测标志物和治疗靶点：MT-high T细胞的发现

IgG-FcγRIIB通过HCK依赖性途径抑制巨噬细胞衰老进而缓解肺纤维化

HIF1α–ENO1–PAD4信号轴驱动NETosis介导肺动脉高压血管重塑的机制研究

酪氨酸激酶Lyn激活JAK1/STAT6信号通路促进嗜酸性粒细胞活化和哮喘炎症

单细胞测序揭示CD8+T细胞耗竭及STAT1+CD4+T细胞缺失驱动恶性胸腔积液进展

A foundation model of deep phenotyping reveals immune biomarkers and subtypes in chronic obstructive pulmonary disease

TREM1调控巨噬细胞细胞外囊泡mtDNA介导慢阻肺病肺血管内皮细胞凋亡

GSDMB介导的核酸识别与STING信号激活在哮喘固有免疫失衡中的作用机制研究

CXCR3剪切变体在ARDS的时空表达及差异性抑制的调控研究

A Multi-targeting Chimeric Antigen Receptor-T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Solid Tumors

KAT5介导的MLKL乙酰化修饰调控巨噬细胞源性外泌体分泌促进肺纤维化

Targeting FOXM1 reprograms Tumor-Associated Macrophages to M1 phenotype and Enhances CD8+ T Cell-Mediated Anti-Tumor Immunity

中性粒细胞 NETs–BAFF/APRIL 信号促进 B 细胞 IgA 产生及其与肺移植不良结局的关联

B-cell activating factor induces systemic lupus erythematosus-associated pulmonary arterial hypertension via GZMK+ CD8+ T cell mediated endothelial cell apoptosis

去泛素化酶通过调节巨噬细胞胞葬在铜绿假单胞菌肺炎转归中的作用及机制研究

Deep multi-omics profiling reveals three distinct molecular subtypes of chronic obstructive pulmonary disease in a unique biomass-exposed Chinese population

蛋白靶向降解减毒活疫苗策略

消除ADE效应的寨卡疫苗在非人灵长类动物中的免疫学基础

纳米锰佐剂递送抗原增强免疫应答的作用及机制研究

基于框架核酸的新型高效亚单位疫苗研究

TLR2 Agonist aBA from Borrelia Functions as a Self-Adjuvant for Nanoparticle Vaccine to Induce Potent Mucosal Immunity

基于脂质的 LMP1-mRNA 疫苗

A Trained Immunity-Based Adjuvant Platform Using Probiotic Nanovesicles to Augment mRNA Cancer Vaccines

FcRn-Driven Nanoengineered Mucosal Vaccine with Multi-Epitope Fusion Induces Robust Dual Immunity and Long-Term Protection Against Brucella

CD8+ T细胞诱导与记忆的调控机制与增强技术

富集肿瘤新抗原的个性化仿生癌症疫苗的开发和机制研究

Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control

“以快制快”——应对X疾病的新型环状RNA疫苗及单抗研发技术平台

中国东北人群SARS-CoV-2疫苗接种后的免疫学分析

Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system

Igκ Drives Liver Regeneration by Stabilizing MYLK to Maintain Cytoskeletal Integrity and Promote Hepatocyte Proliferation

Tumor cell-intrinsic PD-1 in malignant ascites drives ovarian cancer progression via MAPK/ERK signaling

WTAP介导m6A修饰调控巨噬细胞炎症促进银屑病进展

Notch signaling regulates the differentiation and function of monocyte/macrophages in nervous system disease

Mitochondrial Retrograde Signaling Mediates Oxidative Stress-Induced Intrinsic Inflammation in Pancreatic β-Cells

Intestinal CD8+ γδ T cells Shift from Immune Activation to Suppression and the Concomitant Impairment of Cytotoxicity as Disease Activity Increases in Patients with Ulcerative Colitis

IFI208, a novel interferon-stimulated gene, promotes host antiviral responses through liquid-liquid phase separation of MDA5

PRC2亚基EED与EZH2拮抗性调控巨噬细胞中NLRP3炎症小体活化的机制研究

金黄色葡萄球菌胞外囊泡通过p38 MAPK-MerTK脱落介导的巨噬细胞胞葬抑制延缓皮肤伤口愈合

HnRNPA2B1通过识别线粒体DNA激发抗RNA病毒天然免疫应答

Fam234a acts as a switch for Th17 versus Treg cell fate decision that controls inflammatory bowel disease

NUFIP1通过PRPF19复合体维持mRNA稳态调控T细胞存活及抗病毒功能

T cell help promotes reentry of rare memory B cells into germinal centers and contributes to generation of anti-influenza broadly neutralizing antibodies

全生命周期全细胞类型人胸腺衰老图谱

AIM2 regulates B cell activation and function through the SNX9-PI3K-WASP axis

抗原识别受体多样性的演化及其潜在应用

Distinct epitopes and mechanisms enable broadly protective anti-NA antibodies against HxN1 influenza viruses

Dcn+成纤维细胞在ARDS肺纤维化中的免疫调节作用：从炎症到纤维化的分子桥梁

Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses

STING activates ZBP1-mediated PANoptosis to defend against HSV-1 retinal infection

A Precursor-like Vδ1+ γδ T Cell Subset Sustains Effector Responses to Recurrent Malaria Infections over 10 Years

CypA通过阻碍RSV-N与PKM2的相互作用限制有氧糖酵解从而激活干扰素信号

Study on the Inhibition of Hantaan Virus Infection by Artificial Intelligence-Designed Antimicrobial Peptides

Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages

Schlafen家族蛋白抑制病毒复制分子机制

CD300A⁺ CD8⁺ T细胞介导干扰素治疗乙肝功能性治愈的免疫机制及临床意义

宿主双向转运抗菌代谢物itaconate的功能与机制研究

m6A reader IGF2BP3 impairs host antiviral innate immunity against RNA virus by stabilizing SOCS3 mRNA

基于冻存组织的肺-免疫双人源化小鼠模型用于人类低致病性冠状病毒感染与免疫研究

Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody

PATZ1在PML核体附近形成的凝聚体抑制HBoV转录发挥天然抗病毒作用

Influenza Virus Hijacked RBM22 to Dampen Alveolar Macrophage Self-renewal and Host Defense through Modulating Fatty Acid Metabolism

RNF213 regulates BBB integrity by targeting TRAF3 for type I interferon activation during A. baumannii infection

The IL-1β-CXCL1 axis mediates CXCR2+ neutrophil recruitment by IL1R1+ Adventital fibroblasts in influenza virus Infection

Glucose Restriction Shapes Pre-Metastatic Innate Immune Landscapes in Lung through Exosomal TRAIL

胆固醇衍生物7α-25-OHC及其受体GPR183 调控巨噬细胞促进肿瘤转移的功能和机制研究

YY1乳酸化诱导CARD9缺陷抑制树突状细胞促进胰腺癌免疫逃逸机制研究

瘤内链球菌属通过抑制CD8+T细胞功能调控肝细胞癌免疫逃逸的研究

CEBPD通过调控PDHA1乳酰化修饰促进早期肺腺癌免疫逃逸的机制研究

肿瘤相关成纤维细胞通过CHI3L1-SIGLEC15信号轴调控肿瘤相关巨噬细胞脂质代谢促肿瘤的机制研究

Epigenetically targeting PRMT5 promotes antitumor immunity by inducing endogenous retroviruses expression and triggering viral mimicry response

Autophagy-Mediated Secretion of Intracellular ALDH1L1 Drives Pro-Tumorigenic Humoral Immunity in Hepatocellular Carcinoma

Self-DNA controls the stemness and immune editing function of cancer stem cells

NEU破坏NK细胞功能促进肿瘤进展

TRIM21促进STAT1的K33泛素化进而增强CXCL10分泌和抗肿瘤效应作用与机制研究

阿司匹林通过解除免疫抑制防止癌症转移

Macrophage antigen presentation in cancer

SLC1A3介导的谷氨酸代谢重编程通过DOCK2-RAC1信号通路增强肝细胞癌中M2型巨噬细胞极化

E2F7驱动祖细胞状态转换促进高危神经母细胞瘤的转移

Cancer cells evade immune attack through downregulating IL-33 to facilitate the differentiation of immunosuppressive CX3CR1⁺IL-1R1⁺ tumor-associated macrophages

A Novel Microenvironment-Based Subtype of Small-Cell Lung Cancer: Multi-Omics Profiling, Therapeutic Vulnerability Discovery, and AI-Powered Prediction Tools for Precision Therapy

Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8+ T cells activate host CD4+ T cells to control tumors with antigen loss

IFNγ augments TKI efficacy via alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma

TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens

Intracellular Secondary Response–Empowered Intelligent Switch for In Vivo CAR-T Therapy

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8⁺ T Cells by Inhibiting S100A8/A9-CD36 Axis in Obesity-Associated Pancreatic Adenocarcinoma

Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRAS G12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors

HIF2α deficiency improves NK cell antitumor activities in the hypoxia tumor microenvironment

STING-TOX-HO-1信号介导乳酸诱导肿瘤浸润CD8+T细胞铁死亡的分子机制及抗肿瘤免疫治疗研究

PA-MSHA synergizes with immune checkpoint blockade via macrophage-driven tertiary lymphoid structures

Targeting Myeloid-derived Suppressor Cells via TIPE2 Immune Checkpoint Potentiates Oncolytic Adenoviral Therapy

免疫抑制剂耐药的通用型CAR-T细胞的抗肿瘤治疗研究

Histone lactylation driven by the mTORC1 pathway impairs ITNK cell persistence via promoting terminal effector differentiation

NKG2A介导的HTR2B下调损害肿瘤浸润虚拟记忆T细胞的抗肿瘤功能机制研究

Novel immunopyroptotic protein Inhibits HER2-positive solid tumors growth and Reverses Tumor Immune Desertification by Motivating the Anti-Tumor Immune Response

Fructose-1,6-bisphosphatase 1 Induced Vascular Normalization Enhances the Efficacy of Immunotherapy in Lung Adenocarcinoma and Its Mechanism

Inhibition of in situ abdominal cancer, glioma, and post-surgery melanoma recurrence via a peptide hydrogel releasing CAR-T cells and CXCL9

类风湿关节炎精准诊断及对因治疗

Identification of a metabolic-immune crosstalk in AOSD/MAS: monocyte/macrophage-derived immunomodulatory metabolite itaconate dictates hepatic immunopathology via CXCL10-CD8 T-cell axis

基于PHIP-Seq 技术的自身免疫性脑炎新型抗体发现与鉴定

通过整合孟德尔随机化、转录组学和单细胞测序技术揭示APOL6+单核细胞在系统性红斑狼疮炎症进展中的重要作用

Analytical strategy of TCR clusters shared by infection and autoimmune diseases

TREM2 Drives Neutrophil Extracellular Traps-Induced Dendritic Cell Maturation and Contributes to Lupus Progression

黄连细胞外囊泡通过恢复锌稳态抑制中性粒细胞外诱捕网形成缓解炎症性肠病的作用机制

ALA重塑能量代谢抑制γδT细胞活化改善银屑病炎症的机制研究

转录因子ZBTB32抑制系统性红斑狼疮中与年龄相关的B细胞的形成

PTPRC新发突变致TCR信号通路部分损伤引发非经典型SCID

Upregulation of ICOS+Treg Cells and Elevated Serum ICOSLG as Potential Diagnostic Biomarkers for Pre-Clinical Rheumatoid Arthritis

A Multi-criterion Feature Integration Framework for Accurate Diagnosis of Sjögren's Disease Using Routine Laboratory Tests: A Multicentre, Retrospective Cohort study

α-Ketoglutarate alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by promoting the expression of CD39

P2X7R of synovial fibroblasts is a therapeutic target in refractory rheumatoid arthritis

CD19/BCMA双靶点CAR-T治疗系统性红斑狼疮的骨髓B细胞重建规律研究

Therapeutic effect and mechanism of calycosin derivative CA028 on experimental autoimmune encephalomyelitis

Brg1-imprinted chromatin status regulates effector and memory ILC2 metabolism to exacerbate exacerbate allergic lung inflammation

靶向CHERP恢复角质形成细胞PP6抑制增生性皮肤疾病模型炎症的机制研究

乳酸通过PRDX1乳酸化增强IgA浆细胞功能以模拟运动对IBD的保护作用

TCRαβ+CD4-CD8-T细胞在牙周炎中的免疫调节作用及治疗机制研究

靶向肠道菌群代谢以调控免疫：基于烯酰辅酶A水合酶的菌群干预策略

Keratin 17 Enhances the Chemotaxis of Neutrophils through Regulating CXCL1 Secretion in Keratinocytes via PI3K/AKT/NF-κB Pathway in Psoriasis

Fibroblast LRRK2 promotes neutrophilic skin inflammation in psoriasis via Iκbζ/p50 signaling

Secretomes from combination cytokine-activated MAIT cells restore carbapenem activity against carbapenemase-producing bacteria

Lian Qiao Wen Dan Decoction Attenuates Gastric Carcinogenesis by Alleviating Oxidative Phosphorylation Dysfunction

Fine-tuning the Sympathoadrenal Medulla Pathway with Acupuncture to Drive Immunomodulation Against Inflammation

7E7 inhibits lung cancer growth through enhancing NK cell cytotoxicity

Dunhuang Gancao Fuling Xingren decoction and its components alleviate CPT-11 induced intestinal mucositis by regulating gut microbiota dependent innate immunity and inflammatory response in Drosophila and mice

金钗石斛通过调控精氨酸/脯氨酸与甘油磷脂代谢通路介导免疫代谢稳态改善2型糖尿病作用机制研究

月华丸通过重塑炎症微环境和抑制MDSC-ARG1轴逆转结核感染中的T细胞耗竭

Dihydroartemisinin inhibits histone lactylation through YAP1 to act as a ‘hot’ switch for ‘cold’ tumor in hepatocellular carcinoma

从巨噬细胞M2极化介导的免疫抑制微环境探讨萎胃汤干预胃黏膜肠上皮化生的作用机制

AhR-Siglec-15 通过 TRPML1 调节溶酶体钙离子释放促进SHH亚型髓母细胞瘤生长

Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation

Neddylation targets and stabilizes NLRP3 to augment inflammasome-mediated colitis and mood disorder

星形胶质细胞通过自分泌HMGB1抑制胆固醇生物合成损害髓鞘再生

肠道免疫对精神压力的保护作用

Alteration of intestinal mucosal immunity and metabolites in mice exposed to chronic restraint stress

母体自然杀伤细胞异常分泌胞外颗粒酶B驱动子代神经免疫疾病

Microglia–Neuron Interactions Promote Chronic Itch via the NLRP3-IL-1β-GRPR Axis

膳食益生元/益生菌/后生元通过结合mGluR4受体经AC-cAMP-PKA-NF-κB/NLRP3通路抗精神分裂症神经炎症的机制研究

IL-33/ST2 deficiency induces anxiety- and depression-like behaviors through neuroinflammation in the medial prefrontal cortex and hippocampus

单细胞空间转录组分析确定慢性活动性多发性硬化症病变中的致病炎症微环境

Stromal cell–macrophage metabolic crosstalk via itaconate promotes immune imbalance in endometriosis

果糖摄入驱动糖酵解-ROS-EGFR轴特异性促进pTH17的生成和致病性

PPARγ介导脂代谢重编程在高脂饮食致胸腺上皮细胞衰老中的作用及干预

Malate remodels mitochondrial metabolism and limits inflammation via TBK1 binding in macrophages during K. pneumoniae-induced sepsis

基于透明抗体微珠及介电泳微流控芯片的小细胞外囊泡液体活检技术研究

In-Depth Serum Proteomics Atlas of COVID-19 Defines a Severity-Resistance Index from a Four-Protein Panel for Disease Severity and Prognosis

基于特定T细胞精细亚群线粒体功能状态的免疫代谢新指标辅助肿瘤诊断

Intrauterine infusion of autologous-induced CD49a+ NK cells for patients with unexplained recurrent pregnancy loss and implantation failure

基于机器学习与髓系细胞免疫表型评分模型对脓毒症作早期快速诊断

针对四连接素TN致病表位P5-5单克隆抗体的开发及其在败血症诊断与治疗中的转化应用

新型布鲁氏菌诊断抗原蛋白 ST 的研发与评价

A sensitive, fast, and efficient method for studying NETosis ex vivo by flow cytometry and live cell imaging

细胞相互作用的活体化学“垂钓”

子宫NK细胞的功能及其在治疗不孕不育领域的临床应用

评估基于梅毒螺旋体抗原的半定量荧光素酶免疫吸附测定法（LISA）在梅毒诊断与治疗监测中的临床应用价值

单细胞生物功能集成技术助力抗体药研发和肿瘤免疫治疗

通过调控抗原收集、制备和纯化等各类参数优化升级癌症疫苗及免疫治疗疗效预测生物标志物

Novel Combination Approaches to Enhance CAR-T Cell Efficacy in Solid Tumors Through Tumor Microenvironment Remodeling

Thermal-responsive activation of engineered bacteria to trigger antitumor immunity post microwave ablation therapy

Single cell resolved spatial immune repertoire unveils spatial heterogeneity of lymphoid aggregates in human immune disorders

基于新型多模态分子影像技术的免疫细胞在体示踪及量化研究

免疫表型组库及其分析策略之思考

8CLC-derived Exosomes Mediate Regulatory T-Cell Retinoic Acid Metabolism Through CRABP to Alleviate Psoriasis

一种用于体内实时追踪CAR-T细胞的PET报告基因系统建立

生物力学调节巨噬细胞炎性的机制及其在创面愈合中的作用研究

系统性红斑狼疮患者神经精神受累的生物标志物

Cryo-thermal therapy enhances anti-PD-1 efficacy through CCL5+ mature myeloid cell-mediated tumor microenvironment remodeling

AI辅助设计的TCR蛋白功能性优化与新型TCR蛋白药物研究

单细胞与空间转录组分析揭示垂体神经内分泌肿瘤进展中的肿瘤异质性与免疫重塑

T细胞衰老削弱疫苗效力的机制研究

Targeting PD-L1 triggers elimination of senescence cells for diabetic wound healing

Immunomodulatory effects of 2'-Fucosyllactose on Immunosenescence

The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer

富勒烯材料通过调控免疫治疗自身免疫性疾病的研究

C. m boosts arginine production to alleviate myeloid-derived suppressor cell-mediated immune suppression in sepsis

基于工程化凋亡囊泡膜递送线粒体的免疫重编程与疾病治疗研究

呼吸道菌群及其与宿主免疫的互作

Respiratory Commensal Streptococcus Regulates Innate Immunity to Protect Against Influenza Infection

基于高通量测序的呼吸道病毒感染抗体组库动态特征与免疫应答机制研究

微波来源肿瘤细胞微颗粒通过富集HMGB1诱导肿瘤细胞免疫原性细胞死亡治疗肺腺癌

Kyn-AhR-SLC39A10-Zn2+信号通路重编程巨噬细胞并增强吡非尼酮治疗肺纤维化的疗效

香烟诱导肺泡巨噬细胞形成训练免疫促进慢性阻塞性肺疾病频繁急性加 重表型的机制研究

整合多组学数据构建急性呼吸窘迫综合征单细胞图谱

新冠病毒感染后肺部遗留损伤者气道免疫景观的单细胞分析

呼吸道病毒感染重症化的代谢-免疫调控机制

新冠患者肺气道特异性T细胞免疫特征研究

流感轻症患者髓系细胞免疫反应的时间序列图谱：单细胞分析揭示动态变化

OM-85 Prevents Influenza Virus Infection by Increasing CD4⁺ TRM Cells through PLZF-Regulated IL-15/IL-15Rα Signaling

单细胞图谱揭示变应性支气管肺曲霉病的免疫失衡与治疗重塑

Multi-omics Analysis Reveals Distinct Spatial Compartmentalization of Lung Repair Niches in Pediatric ARDS

LGALS3 亚群驱动中性粒细胞聚集促进病毒性肺炎ARDS的发生

Chemerin-CMKLR1轴改善特发性肺纤维化的作用及机制研究