Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8+ T cells activate host CD4+ T cells to control tumors with antigen loss

IFNγ augments TKI efficacy via alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma

TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens

Intracellular Secondary Response–Empowered Intelligent Switch for In Vivo CAR-T Therapy

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8⁺ T Cells by Inhibiting S100A8/A9-CD36 Axis in Obesity-Associated Pancreatic Adenocarcinoma

Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRAS G12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors

HIF2α deficiency improves NK cell antitumor activities in the hypoxia tumor microenvironment

STING-TOX-HO-1信号介导乳酸诱导肿瘤浸润CD8+T细胞铁死亡的分子机制及抗肿瘤免疫治疗研究

PA-MSHA synergizes with immune checkpoint blockade via macrophage-driven tertiary lymphoid structures

Targeting Myeloid-derived Suppressor Cells via TIPE2 Immune Checkpoint Potentiates Oncolytic Adenoviral Therapy

免疫抑制剂耐药的通用型CAR-T细胞的抗肿瘤治疗研究

Histone lactylation driven by the mTORC1 pathway impairs ITNK cell persistence via promoting terminal effector differentiation

NKG2A介导的HTR2B下调损害肿瘤浸润虚拟记忆T细胞的抗肿瘤功能机制研究

Novel immunopyroptotic protein Inhibits HER2-positive solid tumors growth and Reverses Tumor Immune Desertification by Motivating the Anti-Tumor Immune Response

Fructose-1,6-bisphosphatase 1 Induced Vascular Normalization Enhances the Efficacy of Immunotherapy in Lung Adenocarcinoma and Its Mechanism

Inhibition of in situ abdominal cancer, glioma, and post-surgery melanoma recurrence via a peptide hydrogel releasing CAR-T cells and CXCL9